Delta Air Lines started scheduled passenger services in June 1929 between Dallas, TX and Jackson, MS as Delta Air Service Inc. On its merger with Chicago & Southern Air Lines on 1 May 1953, Delta became Delta C & S  Air Lines, and Chicago & Southern's six L-649As were also taken over. Three of them were, however , sold to TWA in April 1954, while the other three were retired for use on daily First class services from Chicago to New Orleans, Havana, Montego Bay and Caracas, and from Chicago to St Loius, Memphis, Jackson and New Orleans. By the beginning of 1955, DC-7s had taken over on the former of these two routes and DC-6s on the latter, and the three Connies were sold to Pacific Northern Airlines. In February 1956, however, four 049s were purchased from Pan American after the award of the Dallas to NY route. The 049s, after modification to Delta's requirements, were placed in service on th Coach class schedules in July 1956. The following year the C & S part of the airline's title was dropped, and in 1958, after all DC-7s had been delivered, the 049s were withdrawn from service and put up for sale. They were sold in 1960.